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Controls: Detailed button mappings for all control types (A-F), including analog stick and D-pad functions for movement, aiming, shooting, reloading, and communication. Special abilities are executed by combining R1/R2 with the Cancel button.

Game Difficulty: Explains the five difficulty settings: Easy (abundant resources, weak enemies), Normal (balanced resources), Hard (scarce resources, tougher enemies), Very Hard (extremely scarce resources, tough enemies), Lone Wolf (no partners), and Infinity Mode (infinite ammo, melee weapons, and First Aid Sprays).

Electrocardiogram (Health Status): Describes the health indicators: FINE (Green, full health), CAUTION (Yellow, minor damage), CAUTION (Orange, low health, reduced movement), DANGER (Red, near death, crawling, rapidly expiring virus meter), POISON (requires Blue Herb or Antidote), and BLEED (slows movement, requires Hemostatic or First Aid Spray).

Health-Replenishing Items: Lists and describes the effects of Green Herbs, Blue Herbs, Red Herbs (when combined), First Aid Sprays, and various combinations of herbs. Notes that in DANGER mode, healing properties are disregarded but allow the player to stand up.

Medicine: Details medicine items that can be crafted by George or found in-game, including Recovery Medicine (equivalent to a Green Herb), Recovery Medicine (L) (equivalent to 4 Green Herbs), and Hemostat (stops bleeding).