Welcome to Los Santos! Grand Theft Auto V throws you into the sprawling, sun-drenched metropolis where three very different criminals—Michael, Franklin, and Trevor—plan and execute a series of daring heists. You'll navigate a world filled with opportunities for mayhem, from high-speed chases and intense shootouts to exploiting the stock market and uncovering the city's many secrets. It’s a wild ride through a satirical take on modern American culture, offering an open world packed with activities for every type of player.
This guide is your essential companion to mastering Los Santos. We'll cover everything you need to know, from planning lucrative heists and understanding weapon loadouts to finding every hidden collectible and easter egg. Whether you're aiming to complete all the main story missions, tackle the Strangers and Freaks encounters, or simply want to exploit the game's deepest systems, this guide will help you conquer every challenge and uncover the game's most elusive secrets across all platforms.
The Los Santos Drug Wars DLC
Discover the Los Santos Drug Wars DLC for GTA Online! Learn about new missions, the Acid Lab, vehicles, weapons, and festive content. Get ready for the December 13th update!
The Los Santos Drug Wars DLC
Discover the Los Santos Drug Wars DLC for GTA Online! Learn about new missions, the Acid Lab, vehicles, weapons, and festive content. Get ready for the December 13th update!
First Dose 2
Follow this Grand Theft Auto V walkthrough to complete the 'Designated Driver' mission, the second part of the First Dose DLC. Learn how to steal a truck, retrieve supplies, and evade the Lost MC.
- 1To start the 'Designated Driver' mission, complete 'First Dose 1 - Welcome to the Troupe'. Then, drive to the abandoned warehouse and enter the yellow circle, pressing up on the D-Pad to begin.
- 2Take any vehicle and follow the waypoint to Jetsam Terminal.
- 3Acquire a Truck Cab and then pick up the nearby trailer by reversing into it.
- 4Follow the waypoint back to the Abandoned Warehouse (The Freakshop).
- 5The Lost MC will set your trailer on fire. Unhook it by pressing up on the D-PAD.
- 6Follow the new waypoint to the Lost MC Clubhouse.
- 7Take cover by the wall outside and eliminate the enemies. Use grenades on vehicles for multiple enemies, and use a Shotgun for approaching MC members.
- 8Once all exterior enemies are cleared, enter the Clubhouse and clear the remaining enemies with your Shotgun.
- 9Enter the door behind the bar and use the Snapmatic App to take a picture of the plans on the whiteboard.
- 10Exit the room, grab the Bag from the Bar, and pack the Weed into it in the back room.
- 11Exit the Clubhouse and take cover immediately, as more Lost MC members will be waiting. Use grenades on their vehicle and finish off any survivors with a Shotgun or SMG.
- 12Take any vehicle and follow the waypoint back to the Warehouse to complete the mission.
- When attacking the Lost MC Clubhouse, throwing grenades at their vehicles is an effective way to deal with groups of enemies.
- If an MC member approaches you directly, a Shotgun is effective for close-quarters combat.
- Conserve your health by peeking out for one kill at a time and retreating to recover if necessary.
- Completing this mission progresses the First Dose storyline and unlocks further missions in the Los Santos Drug Wars DLC. Specific monetary or item rewards are not detailed in the source text.
First Dose 1
Follow this guide to complete the 'Welcome to the Troupe' mission in Grand Theft Auto V's Los Santos Drug Wars DLC, including tips for defeating the Lost MC and recovering Dax's Journey.
- 1Download the latest DLC and boot up Grand Theft Auto V.
- 2Wait for a call from Ron, which should arrive within 5 minutes.
- 3Meet Ron at the Ace Liquor Store in Sandy Shores.
- 4After the cutscene, you'll need to eliminate the Lost MC members who are trying to steal Ron's RV.
- 5Once you regain control, stay in cover on the roof and use a Marksman Rifle for distant enemies. Switch to an Assault Rifle for closer targets. Rocket Launchers and Grenades can be used to destroy enemy vehicles.
- 6If you take damage, get back into cover to regenerate health or use Snacks.
- 7Check your mini-map for more Lost MC members approaching from other areas. Move to their location, get into cover, and repeat the process.
- 8After dealing with all enemies, go downstairs and take the nearby boat marked on your map across the Alamo Sea to reach the dock.
- 9You will encounter more Lost MC members near Dax's Journey. Use boxes for cover and pick them off with your Assault Rifle. Switch to a Shotgun or SMG for enemies that get too close. Watch your mini-map for flanking enemies.
- 10After defeating the enemies, get into the RV and drive back to the Ace Liquor Store to pick up Dax.
- 11Swerve to avoid vehicles blocking your path and drive into or shoot the Motorcyclists approaching you.
- 12Once Dax is picked up, follow the route back to an abandoned warehouse to complete the mission.
- Use cover effectively to regenerate health or avoid damage.
- Utilize different weapons for various ranges: Marksman Rifle for distance, Assault Rifle for mid-range, and Shotgun/SMG for close encounters.
- Pay attention to the mini-map to anticipate enemy movements and flanking attempts.
- Destroy enemy vehicles with explosives for quick elimination of multiple threats.
- Don't hesitate to use Snacks to speed up health regeneration.
First Dose 3
Follow this guide to complete the Fatal Incursion mission in Grand Theft Auto V's Los Santos Drug Wars DLC. Learn how to destroy property, find meth bags, and return to The Freakshop.
- 1To start Fatal Incursion, the third mission of the First Dose portion of the Los Santos Drug Wars DLC, you must first complete First Dose 1 - Welcome to the Troupe and First Dose 2 - Designated Driver.
- 2Drive to the abandoned warehouse and enter the yellow circle. Press up on the D-Pad to begin the mission.
- 3Take any vehicle and follow the waypoint to Stab City.
- 4Destroy the Lost MC's property by using Sticky Bombs on Petrol Tankers, Motorcycles, and Vans. Remain in your vehicle and drive around the loop to deal damage and increase the property bar.
- 5If your health is low, escape and wait for it to recover.
- 6After planting Sticky Bombs, detonate them. Continue destroying property on foot, sticking to the outer edge and picking off enemies. Use cover to destroy more Vans and Motorcycles until the property bar is filled.
- 7Once enough property is destroyed, the objective changes to “Go to Millar’s Fishery”.
- 8Collect 10 bags of The Lost’s Meth. These are found in groups of 2 in the following locations: Long Building on the right, Middle of the Area, Dock, Lab, and Shelves next to the back left building.
- 9While collecting the meth, stay in cover and use an Assault Rifle or Marksman Rifle to eliminate enemies.
- 10After collecting all 10 bags, take the Dodo parked on the water and fly back to The Freakshop.
- 11Land in the Storm Drain to complete the mission.
- Use Sticky Bombs for efficient destruction of property.
- Stay in cover when fighting enemies, especially at Millar’s Fishery.
- Use an Assault Rifle or Marksman Rifle for better accuracy against distant enemies.
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