Your goal: Shoot it until it dies. You should have enough ammo.

Learn the best strategy to defeat Plant 42 in Resident Evil HD Remaster. Discover its weaknesses, attack patterns, and how to use incendiary shells effectively.

Stats / Weaknesses:

• Plant 42 — Weak to Incendiary Shells.

Phases:

1. The plant will attempt to poison you with gas and constrict you with its vines.

Strategy:

• Make your way upstairs to Plant 42's domain.
• Equip your Incendiary Shells.
• Continuously shoot the plant until it shrivels up and dies. You'll need about 10-12 shells.
• Be mindful of its poison gas and vine attacks, but don't worry too much, as this boss is generally considered easy.

Alternate Strategy (Jill Valentine Only):

If you're playing as Jill and want to save ammo and health, you can actually avoid fighting Plant 42 altogether. Here’s how:

1. Before entering Plant 42's area, make sure you have cleared up three item spaces. You'll need to pick up the lighter.
2. Head into the Employee Lounge (where the two spiders used to be). Find a red lamp in a corner to the left of the entrance. Light it and note its color and the symbol shown. Do the same for the green lamp on the left table by the bar, and the orange lamp by the pool table. Pay attention to the pool balls' colors and numbers: Red is 3, Orange is 5, and Green is 6.
3. Go to the Gallery. Examine the keypad next to the first door on the left, on the same side as the entrance. Enter the code you've figured out.
4. Warning: A misstep here could release toxic gas! Grab three empty bottles. Fill one with water at the sink. Fill a second bottle with UMB No. 3 (from the yellow jar) and mix them to get NP-004. Collect some Yellow-6 and mix it with NP-004 for UMB No. 10. Fill another bottle with water and more Yellow-6 to get UMB No. 7. Combine UMB No. 7 and UMB No. 10 to create VP-017. Finally, get another batch of UMB No. 3 and mix it to create the coveted V-Jolt chemical.
5. Take the V-Jolt down to the basement and head to the control room (you can use the Water Rooms to get there, as noted by CVXFREAK). Go up the ladder and out the door. You can optionally eliminate the beach shark with a single handgun shot if you wish, though it's not necessary. Enter the Guard Room next to the shark and walk into the plant's roots – they won't harm you.
6. Give the plant a shot of the herbicide (V-Jolt) and discard the bottles.

When you then enter Plant 42's main area, Barry will arrive and take care of the plant for you, saving you from having to fight it and conserving valuable ammo and health.