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Part 22
Dishonored 2

Part 22

Dishonored 2 Part 22: Craft the Crown Killer cure, disable the turret tower, and learn about special actions like Three Witnesses.

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Dishonored 2 Part 22: Craft the Crown Killer cure, disable the turret tower, and learn about special actions like Three Witnesses.

Walkthrough
  1. 1
    Fill a stoppered flask in the lab with the serum, then heat it.
  2. 2
    Fill a hypodermic needle with the serum.
  3. 3
    Locate the Crown Killer and inject the cure using a nonlethal takedown. This scripted shot replaces the usual sleeper hold attempt.
  4. 4
    To exit Addermire, disable the turret tower in the docks area. Meagan's exit skiff will not spawn until this is done. If the turret is reactivated, Meagan will die, forcing a do-over. Hypatia's lab offers a shortcut to the tower via shutters near where Vasco was.
  5. 5
    Optional: Lethal players can shoot whale oil canisters near the docks to kill two guards.
  6. 6
    Optional: If Hypatia survived the previous mission, collect a 100-coin bonus from the desk in your quarters. She will also move into the cabin across the hall with a crate of Addermire Solution.
  7. 7
    Optional: If Hypatia is present, talk to her about Kirin and Anton.
  8. 8
    Optional: Stop the engine room's water leak by finding a crankvalve in the meeting room area on the bridge and disabling it manually.
Tips
  • Performing the nonlethal Crown Killer takedown counts as a special action and earns a 100-coin bonus in the next mission.
  • Vasco will die during the Crown Killer fight. To achieve the "Three Witnesses" special action, talk to him as soon as possible before initiating the fight.
  • There are unique Heart quotes for the Crown Killer's different forms.
  • The "Souvenirs" trophy requires Vasco's hypodermic needle, which only counts if the cure is created and used on the Crown Killer.
  • Addermire will not be revisited, so ensure you collect all bonecharms, runes, and the mission-specific trophy before leaving.
  • The docks area contains no money or collectibles, so there is no reason to stay after finding all loot.
  • The "Abandoned Basement" special action may require reading Vera Moray's diary to trigger.
  • To perform the "Release the Hounds!" special action, break the glass window of the hounds' locked room, or unlock a side door. This can be done even if guards are dead, as long as the dogs are alive when the glass breaks.
  • The "Sunken Wreck" special action involves visiting the shipwreck underneath the carriage rails, near the level's starting point.
  • To achieve "Three Witnesses," find Valiente's letter (his corpse is in the 2F Disease Treatment wing's abandoned area), save Joe Hamilton from death in the 2F Disease Treatment's normal section (requires Dr. Hypatia's Key), and talk to Vasco in the 2F Recuperation wing (accessed from 3F, also requires Dr. Hypatia's Key). These actions can be done in any order.
  • The "Counter-Serum" special action is achieved by saving the Crown Killer by crafting the antidote in Vasco's lab. Crafting it and then killing the Crown Killer still counts, but doing it in reverse order does not.
  • If Hypatia is present, the serum injector will appear in your quarters' display area for the "Souvenirs" trophy if the Crown Killer matter was solved amicably.
  • The "Royal Spymaster" trophy (Part 2) involves collecting specific journal/audiograph data for Meagan and Sokolov. Items that appear based on player decisions do not need to be collected.
  • Optional objectives for stopping the water leak and talking to Hypatia offer no reward beyond self-satisfaction.
  • Upgraded Dark Vision can help find collectible books, such as "Bloodfly Fever" and "Dr. Hypatia's Notes," provided they are not in brightly lit areas.
  • Trophy: The Beast Within (Deal with the Crown Killer, lethally or nonlethally - mandatory)
  • Trophy: Souvenirs [3 out of 10] (Vasco's hypodermic needle, counts if cure is created and used on Crown Killer)
  • Special Action: Nonlethal Crown Killer takedown (100-coin bonus in next mission)
  • Special Action: Abandoned Basement
  • Special Action: Release the Hounds!
  • Special Action: Sunken Wreck
  • Special Action: Three Witnesses
  • Special Action: The Counter-Serum
  • Optional: 100-coin bonus (if Hypatia survived previous mission)
  • Optional: Addermire Solution (if Hypatia survived previous mission)

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