Part 103

Find all runes in Dishonored 2's Mission 3: The Good Doctor, Mission 4: The Clockwork Mansion, Mission 5: The Royal Conservatory, Mission 6: Dust District, and Mission 7: A Crack in the Slab.

Walkthrough:

1. Mission 3: The Good Doctor (6 runes)
   • In the Addermire Institute's 1F dining room, find a rune affixed to an above-table plaque. This area has three guards who do not patrol, making it trickier for nonlethal runs.
   • Two runes are located in the 4F private rooms block, on an Outsider's shrine. These do not require special circumstances to obtain.
   • After reaching the 4F area with outdoor private housing, go onto the roof of that structure. Look at the tower containing Hypatia's office for an open shutter. Access it via teleportation or a running jump onto the exterior pipework. The rune is inside this small elevator maintenance room, on a table with some coins.
   • In the same elevator maintenance room, call the lift upwards to access its red connector cables. Shoot one, hop in, and let the box fall through 1F into the basement "Lost and Found" area. The rune is next to a gold ingot and a Sokolov painting.
   • Upon entering the 3F Recuperation wing (which requires Dr. Hypatia's Key), you will find a bloodfly nest directly in front of the entrance. The rune is located directly underneath it.
2. Mission 4: The Clockwork Mansion (6 runes)
   • Two runes are inside the first bloodfly apartment (near the sewers where Meagan docks), on a third-floor Outsider shrine. The door to the shrine's flat is locked, but you can hop through a hole in the wall beside it, or use Blink/Far Reach up through the street-facing window.
   • Behind Aventa Station is the Howlers' ambushing alley. A rune is in a cabinet near the initial woman's position.
   • Another rune is sold at the black market for 400 coins. Alternatively, you can rob the shop: traverse the bloodfly apartment above it, then find the robbers in the adjacent building's B1 area attempting to blow a hole in the wall with whale oil tanks. Eliminate them, get a third tank from Aventa Station, and detonate them to gain entry.
   • Past the upper district's wall of light, there is an apartment building (not the one with Jindosh's painting) whose 2F back bedroom contains a rune. In low chaos, this area is inhabited by a husband, wife, and maid; in high chaos, all are dead and bloodflies are present.
   • The final rune is in Jindosh's 1F laboratory, near a surgery table. Manipulating the moving platforms may relocate it to 2F.
3. Mission 5: The Royal Conservatory (6 runes)
   • The first rune is sold at the black market near Seta Canal's ambush alley. You can purchase it or rob the place, which will cause the store to shut down. Robbing it early prevents obtaining the maximum loot, as the shopkeep pays a significant sum for the Roseburrow Prototype in the conservatory. To maximize loot from that quest, find the associate's note in the booby-trapped flat near the conservatory, which mentions being paid double the going rate.
   • Near the cantina past the witch ambush alley, a 3F balcony leads into a booby-trapped apartment. The shrine with two runes is on the 4F level of that building.
   • Inside the conservatory's B1 Forbidden Archive section, a rune is in a display case. The key to this section is in the B1 quartermaster's office (locked, but accessible via courtyard window). You can also enter by pushing the sliding bookcase away from the crawlspace-sized hole on the south side.
   • Another rune is in the 2F lounge area, where corpses have been hit with crossbow bolts. It is on a pillow in a corner.
   • The last rune is on the 4F rooftops, in the sitting area with grapes. If Breanna has not been eliminated, gravehounds may spawn.
4. Mission 6: Dust District (5 runes)
   • After speaking to Meagan in the ruined house, drop to street level and turn around. A boarded-up doorway can be smashed through to find a rune inside an old cabinet.
   • The bloodfly-ridden apartment bordering Valia Street contains a rune in a 2F cabinet, near a nest.
   • In the Overseer Outpost's 2F confiscation room, a rune is within a blue container. The door is locked but can be smashed with upgraded Strength or opened with the key. The overseer carrying it is sleeping in the cot room down the hall.
   • An Outsider shrine is in Paolo's 3F office at the Crone's Hand Saloon, containing two runes. You must infiltrate the office via the inner stairway as the nearest windows are locked from the inside. It is advisable to do this before