Skip to content
Part 21
Dishonored 2

Part 21

Walkthrough for Dishonored 2 Part 21: Confront the Crown Killer. Includes strategies for lethal and non-lethal approaches, item locations, and loot details.

By ···10 min read·Multi-source verified
1 reading this guide  

Walkthrough for Dishonored 2 Part 21: Confront the Crown Killer. Includes strategies for lethal and non-lethal approaches, item locations, and loot details.

Walkthrough
  1. 1
    Save Hamilton: You can save Hamilton by killing the elite guard, pickpocketing his pistol, or creating a distraction. Saving and interrogating him counts towards the "Three Witnesses" special action.
  2. 2
    Loot Joe's Room (2F): Snag the key to Joe's room and loot items within his cell, including disease treatment, a pouch, and copper wire. In Vasco's office (2F), find more disease treatment, a coin, ivory scrimshaw, and a silver ingot.
  3. 3
    Loot Hamilton's Quarters (5F): Optionally search Joe's quarters on 5F. Be cautious of the booby-trapped door. Inside, find mercury vapor distillation blueprints, Hamilton's notes, copper wire coils, bathing salts, and coins. You can also find ammunition and health/mana potions.
  4. 4
    Continue Main Plot (3F): Head to the 3F Recuperation wing, accessible with Hypatia's key. This area is a bloodfly den. Destroy the bloodfly nests and collect three blood amber crystals, a rune, and a bonecharm.
  5. 5
    Loot Showers and Cells (3F): In the wing's showers, find bathing salts and coins. Collect bloodfly husks and a five-coin beneath the bed in the bonecharm cell.
  6. 6
    Loot Hypatia's Lab Area (2F): Find Hypatia's laboratory past the bloodfly area. Before speaking to her, loot for the mission's final coins, including a painting and a coin in a locker. You can also find a corrupted bonecharm.
  7. 7
    Confront the Crown Killer: Speak with Hypatia to learn Sokolov's location. Visit Vasco in the back area, who is recuperating from an attack and can shed light on the Dunwall murders. Listening to his audiograph triggers a battle with the Crown Killer in the main lab.

Crown Killer Strategies:

  • Lethal: Eliminate the Crown Killer using lethal methods such as gunshots, assassinations, springrazors, explosions, or flammable rum bottles. The Crown Killer is resistant to non-lethal methods like stun mines, sleep darts, and R1-based techniques.
  • Non-Lethal: Create a counter-serum. Obtain Vasco's safe combination by speaking to him or reading the note on his body. Go to his office (2F), get the alchemical notes, and unlock his lab to access the apparatuses. Take the base-serum and collect blood from a diseased corpse in the vivarium (bloodfly nest room). Inject the corpse.

Loot Summary:

  • 2F Disease Treatment: 10 coins (Hamilton's cell), 10 coins (Hamilton's cell), 2 coins (Vasco's office), 30 coins (Vasco's office), 75 coins (Vasco's office). Total: 127 coins.
  • 5F Hamilton's Quarters: 10 coins (copper wire), 10 coins (copper wire), 15 coins (bathing salts), 7 coins (coins). Total: 42 coins.
  • 3F Recuperation Wing: 25 coins (blood amber), 21 coins (bathing salts+coins), 5 coins (husk), 5 coins (husk), 25 coins (blood amber), 5 coins (coin), 25 coins (blood amber). Total: 111 coins.
  • 2F Hypatia's Lab: 200 coins (painting), 1 coin (locker). Total: 201 coins.
  • Total Loot: 1852 (from 2F/5F) + 111 (from 3F) + 201 (from 2F) = 2164 coins.

100% Human-Written. AI Fact-Checked. Community Verified. Learn how AntMag verifies content