Learn about all the diseases in Darkest Dungeon, their debilitating effects, and how to cure them at the Sanitarium. Don't let sickness ruin your next expedition!
Alright, let's talk about something that can really mess up your runs in Darkest Dungeon: diseases. These aren't just minor inconveniences; they can cripple your heroes, making them less effective in combat and even affecting their sanity. You'll encounter these nasty afflictions from various sources, like enemy attacks or even interacting with certain curios. The good news is that most of them can be dealt with, but you'll need to know what you're up against.
The primary way to get rid of these diseases is by visiting the Sanitarium back at the Hamlet. It's a crucial building, so make sure you've got it upgraded enough to handle these ailments. You'll need to spend gold to remove them, and some diseases might cost more than others, so keep an eye on your finances.
Here's a rundown of the diseases you might encounter and what they do:
| Disease | Effect |
| Bad Humors | -20% Max HP |
| Black Plague | -75% Blight Resist, -75% Disease Resist, -10% Max HP, -5 SPD |
| Bulimic | -20% Heal Skills while Camping |
| Creeping Cough | -20% DMG |
| Crimson Curse | Up to the effect level, it will remove some resistances, HP points, may increase damage/SPD. |
| Ennui | -25% Virtue Chance |
| Grey Rot | +20% Max HP, -10 ACC, -10% DMG |
| Hemophilia | -50% Bleed Resist |
| Hysterical Blindness | -20 ACC if Stress above 70 |
| Lethargy | -4 SPD |
| Rabies | -10 ACC, +15% DMG |
| Scurvy | -40% Bleed Resist, -40% Move Resist |
| Sky Taint | +20% Stress, -20% Bleed Resist, -20% Blight Resist |
| Spasm of the Entrails | -20% Heal Skills while Camping |
| Spotted Fever | -50% Blight Resist |
| Syphilis | -5 ACC, -10% DMG, -10% Max HP |
| Tapeworm | +100% Food Consumed, Chance of forced interaction with food curios. |
| Tetanus | -5 ACC, -5% CRT |
| The Ague | -10% DMG, -3 SPD, -10% Max HP |
| The Fits | +3 SPD, -5 ACC, -5% CRT |
| The Red Plague | -75% Bleed Resist, -10% Max HP, -5% CRT |
| The Runs | -10% Max HP, -20 Dodge |
| The Worries | +30% Stress Damage |
| Vertigo | -50% Move Resist |
| Vampiric Spirits | -50% Debuff Resist |
Pro Tip: Keep an eye on your heroes' resistances. Diseases often target specific resistances like Blight or Bleed. If a hero is particularly vulnerable, you might want to prioritize curing that disease or equipping trinkets that boost their resistance.
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