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Biodome Navigation & Two-Head Encounter — The Callisto Protocol Guide
The Callisto Protocol

Biodome Navigation & Two-Head Encounter — The Callisto Protocol Guide

Follow our detailed walkthrough for The Callisto Protocol, guiding you through Biodome navigation and the challenging Two-Head encounter. Master combat and find all collectibles.

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Follow our detailed walkthrough for The Callisto Protocol, guiding you through Biodome navigation and the challenging Two-Head encounter. Master combat and find all collectibles.

Walkthrough
  1. 1
    Begin by taking a photo in photo mode for the 'Mugshot' achievement.
  2. 2
    Proceed down the hallway and enter the first locker on the left to find a Bios (1/43).
  3. 3
    Continue to the cargo bay, learning to vault over boxes with !cn_LSu + !cn_A and mantle using the same buttons.
  4. 4
    As you approach a flaming hole, you will earn the 'The Outer Way' achievement.
  5. 5
    Crouch using !cn_B, shimmy through a tight space with !cn_LSu, and sprint using !cn_LB.
  6. 6
    After a cut-scene, hold forward on the left thumbstick to climb back into the captain's chair, ending Chapter 1.
  7. 7
    In Chapter 2, explore your cell during the dream sequence and find the music box.
  8. 8
    Exit your cell, turn right, and take the stairs down to meet Elias. He will give you a shiv, unlocking the 'Desperate Times' achievement.
  9. 9
    Use the shiv on the control panel to unlock Elias' cell, then shimmy past the door.
  10. 10
    In the next room, learn combat mechanics: hold !cn_LSl or !cn_LSr to dodge, then attack with !cn_RT. Alternate dodges for subsequent attacks.
  11. 11
    Defeat the two inmates and the first Biophage. Aim to dismember enemies for the 'Flesh Wound' achievement.
  12. 12
    Unlock Elias' cell with the computer console and proceed to the elevator.
  13. 13
    After taking the lift down, crouch under debris. A Biophage will appear, providing an opportunity to practice perfect dodges by flicking the left stick !cn_LS just before an attack.
  14. 14
    Perform 5 perfect dodges to unlock the 'Float Like A Butterfly' achievement.
  15. 15
    After the fight, find a glowing green wall storage unit to receive a health injector and learn about its use.
Tips
  • The game is significantly easier after a recent patch, making the hardest difficulty manageable.
  • Pay attention to enemy body language to time dodges effectively.
  • Alternating dodges (left and right) is crucial for combat.
  • Perfect dodges require timing the flick of the left stick much earlier than expected.
  • The 'Float Like A Butterfly' achievement can be buggy; try to obtain it early.
  • Mash !cn_Y to escape grabs and stomp on defeated enemies.

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