The Royal Physician

Drawbridge Way: Blink up to the light in front, then to the balcony on the left. Enter Pratchett's house. Choke out Pratchett and find his safe on the top floor. The combination is 4-7-3, with the numbers hidden in three paintings. Inside, you'll find a Rune (2/5).

Return to the stairwell and climb to the roof. Use the Heart to find a nearby Rune. Cross the rooftop. Wait for the enemy on the balcony below to enter the apartment, then blink over and take him down. Find a Rune (3/5) at an outsider shrine in the corner. Jump out the window and head down to the street. Turn left and follow the path until you find a gate. Turn left, climb the stairs, and go around the corner.

Blink up to the roof to the right of the boarded-up window. Use the vents to access a higher roof. Use sleeper darts to pick off enemies in the courtyard below, being mindful of the arc pylon. Stay to the right side of the bridge to avoid it.

From the roof, look down to the right and take out the thug. Use the vents to drop down to the gated area. Make your way along the side of the bridge opposite the arc pylon.

At the far end of the bridge, instead of continuing forward, find the smaller bridge leading down to the left. Blink onto the structure directly in front, rather than entering the room below. On the far side, find a hatch. Open it, and when guards separate, drop down behind the closest one and choke him out. Drag him to the balcony on the left and pull the whale oil canister from the socket to disable the arc pylon.

From the gear, blink across to the top of the drawbridge and continue to the far side. Climb down the chains and drop to the metal grating below. You should be above the objective marker. Look towards the outside of the bridge for a small platform. Blink to it and turn back towards the objective marker.

Blink to the platform below and climb through the opening into the room with the light controls. Remove the whale oil canisters to disable them. Hop back out the window and blink to the opposite side of the bridge. Find the drawbridge controls and pull the lever to lower the bridge. Make your way down the bridge, dealing with or avoiding the three guards. At the bottom, you'll find another arc pylon.

Optional: Help the Scavenger: After speaking with the scavenger, find the key on a table in the room with the alarm on the same floor. Return and follow him. He will ask you to kill five river krusts (large, spiky oyster-like growths). Hit them with a crossbow bolt when they open to spit. They are located two on a rock opposite, two on the roof, and one on a washed-up boat below. Killing them does not count as a kill.

Continue following the scavenger to a locked gate. You can climb over it. If you unlock it, he will attack. To get the promised pearls, blink up to the open window to the right and take out his two companions inside to grab them.

Midrow Substation: Upon entering, find a Rune (4/5) on a table. Explore for cash and elixirs. Drop out the open window and blink to the top of the structure in front and to the right (a control room for spinning gears).

Wait for the guard on the catwalk below to enter the control room beneath you. Drop down and incapacitate him. Pull the lever to stop the spinning wheels. When clear of guards, blink from the platform to the top of the furthest wheel, then down to the fenced area next to the wall of light. Pull the whale oil out of the socket. Blink up to the air-conditioning vent above and to the right. When safe, drop over the fence and go through the now inactive wall of light. Continue towards the objective marker.

Optional: Save the Survivor: Before entering 'Sokolov's House', notice a locked door on the raised platform to the left. Use nearby vents to climb.