Poison Builds

Excel in Slay the Spire with Poison builds. Apply and amplify damage using Noxious Fumes and Catalyst, overpowering foes with escalating poison effects.

Poison builds focus on applying and amplifying Poison damage over several turns. Core cards include Deadly Poison, Noxious Fumes, and Catalyst. Relics like Snecko Skull enhance poison application. This build excels against high-HP enemies and bosses, as poison damage scales exponentially. Ensure you have enough block and card draw to survive while the poison ticks down your enemies. Bouncing Flask is also a great early pick.