Skip to content
Slime Boss
Slay the Spire

Slime Boss

Conquer the Slime Boss in Slay the Spire: manage splits, utilize AoE or burst damage, and consider poison strategies.

By ···10 min read·Multi-source verified
1 reading this guide  

Conquer the Slime Boss in Slay the Spire: manage splits, utilize AoE or burst damage, and consider poison strategies.

The Slime Boss starts as one large entity and splits into two smaller slimes when its HP drops below a certain threshold. These smaller slimes then split again. The key is to manage the splits. Ideally, you want to deal enough damage to split it into two slimes of roughly equal HP, then finish them off with AoE or burst damage before they split further. Poison is very effective here, as it continues to tick on all slimes.

Slime Boss - Slay the Spire screenshot
Slime Boss

100% Human-Written. AI Fact-Checked. Community Verified. Learn how AntMag verifies content