The Final Manifestation Strategy

Character Selection: Choose Judas. He starts with 1 Red Heart container, 3 coins, and The Book of Belial, boasting a 1.35x damage multiplier.

Black Judas Transformation: Dying with Judas' Shadow in your inventory transforms you into Black Judas. This form has a 2x damage multiplier, 1.1 base speed, and starts with two Black Hearts. Black Judas has the highest damage multiplier of all playable characters.

Health Management: Judas has low starting health. Prioritize health upgrades and be cautious with Devil Deals. Items like Dead Cat are less detrimental early on.

Item Synergies: Items that activate on low health (Scapular, Monkey Paw, Glyph of Balance, Whore of Babylon) are easily triggered.

The Book of Belial: This starting item is powerful. Its damage increase is significant, and in Rebirth, it guarantees a Devil or Angel Room. In later DLCs, it increases the chance by 12.5%.

Birthright Interaction (Repentance+): With Birthright, The Book of Belial becomes a passive item, granting a damage boost that scales with the charges of the active item above it. This may not work with all item types.