Advanced Combat Techniques — Enter the Gungeon Guide

Discover how items combine in Enter the Gungeon! Learn about Synergy Factor, how synergies work, and a full list of item combinations to unlock powerful effects.

Hey there, Gungeoneer! So you've been diving deep into the Gungeon and are ready to start mixing and matching items for some truly awesome effects? That's where Synergies come in! Think of them as special combos that happen when you hold certain items together. You'll know a synergy is active because a cool light blue arrow will pop up above your character for a bit. These synergies got a big overhaul in the Advanced Gungeons & Draguns Update. Not only did they add a bunch of new ones and make them easier to get, but each one now has a name! You can even check what's synergizing in your Ammonomicon by selecting an item and seeing the others highlighted. Pretty neat, right? ### Notes Just a heads-up: if a synergy involves guns, any stat boosts from it usually only apply to those specific guns. Sometimes, the synergy might only work with one of the weapons involved. ### Synergy Factor Now, let's talk about something called 'Synergy Factor.' It's a hidden stat that basically nudges the game to give you a synergy if you haven't found one yet. It's like the game saying, "Hey, maybe try this combo!" Synergy Factor starts off pretty high (around 1.7999882 times more likely to see synergies) and goes down the more synergies you get in a run. It only resets when you start a new run or beat the game. It's a multiplier on the base chance of finding items that trigger synergies. Here's how it breaks down: * 0 Synergies: 1.7999882x likelihood * 1 Synergy: 1.120989x likelihood * 2 Synergies: 1.02681x likelihood * 3 Synergies: 1.00829x likelihood After you've gotten a couple of synergies, this factor doesn't really impact your gameplay much. Also, dropping a synergy item before opening chests won't change your Synergy Factor. Interestingly, your starting Synergy Factor can be higher on a fresh save file (starting at 6.0, or 6 times more likely!) if you haven't progressed too far. The deepest floor you've visited multiple times can also affect your initial Synergy Factor. ### List of Synergies This is where the fun really begins! Here are some of the amazing combinations you can find: 360 Yes Scope * Items: Scope + A.W.P. OR Sniper Rifle * Effect: Spin around 360 degrees, and for the next 3 seconds, your next shot gets a 1.5x damage boost. You can stack this buff up to six times if you keep spinning! Absent Minded * Items: The Membrane + Bouncy Bullets * Effect: Shots from The Membrane will bounce up to 4 times and also become homing. Added Effect - Fire * Items: Alpha Bullet + Hot Lead * Effect: The very first shot from each magazine will be a fire bullet. Added Effect - Ice * Items: Alpha Bullet + Frost Bullets * Effect: The first shot of every magazine will be an ice bullet. Added Effect - Poison * Items: Alpha Bullet + Irradiated Lead * Effect: Your first shot from each magazine will be a poison bullet. Akey Breaky * Items: AKEY-47 + Shelleton Key * Effect: The AKEY-47 gets a serious damage boost (10 damage per bullet!), infinite ammo, and it'll look like a Shelleton. It won't be able to open locks by shooting them anymore, though. AI Assistant * Items: Roll Bomb + iBomb Companion App * Effect: Roll bombs will bounce around instead of exploding right away, and you can detonate them manually using the iBomb Companion App. Air Support * Items: Air Strike + ... (This synergy seems incomplete in the source, but likely involves another item to activate!)