Learn where to find Plague Ichor in No Rest for the Wicked by defeating bosses. Discover the best upgrades for your gear, inventory, and character with this guide.
Plague Ichor is a crucial currency in No Rest for the Wicked, primarily used for upgrading your gear and inventory slots. You'll primarily obtain it by defeating bosses, both those tied to the main story and side quests. Don't forget to revisit old boss arenas and tackle weekly objectives for additional drops!
Bosses that drop Plague Ichor:
| Boss | Location | Context |
| Warrick | First Boss in Orban Glades | Part of the Sacrament Quest |
| Darak (second time you fight him) | The Black Trench | Area unlocks via the Rats questline |
| Riven Twins | Nameless Pass | Part of the Servant of God main story quest. |
| Nith Leviathan 1 | Orban Glades | Complete the Rat Quest and go to where you fought Darak during the early part of the Rats quest. |
| Nith Leviathan 2 | Nameless Pass | Complete the Servant of God quest and a Nith Leviathan should appear where you battled the Riven Twins. |
| Torn Colossus | Sacrament War Room | Pick up the Within Our Walls weekly challenge from Sacrament |
| Brutal Couplet | Shallows | Pick up the A Savage Pair weekly bounty from Sacrament to spawn the two mini bosses on the beach south of Mariner’s Keep. |
After collecting your Plague Ichor, return to the Rookery or Sacrament and speak with the old man and his assistant. This is where you'll turn in the ichor and make your upgrade choices.
Best Upgrades to Prioritize with Plague Ichor
When deciding how to spend your hard-earned Plague Ichor, consider these upgrades carefully:
- Ring Slots
- Offhand Slot
- Gear Slots
- Resource Slots
Upgrading your offhand slot once is highly recommended, especially if you use builds that benefit from ranged options like a bow. This can significantly help in dealing with annoying ranged enemies from a distance.
Similarly, investing in your ring slots is a no-brainer for mid to late-game progression. More ring slots mean access to additional gear, gem slots, and valuable stat boosts.
Don't overlook expanding your resource and gear inventory. More space means you can carry more loot, potentially finding better gear or having more items to sell to traders. It's also essential for gathering the wide variety of unique resources needed for crafting, cooking, and schematic upgrades.
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